Advancing Protein Sequencing with Single-Particle Mass Spectrometry

Conventional bottom-up proteomics often leaves critical gaps, providing only partial protein information and missing key sequence details. ImmPro’s ProteoSight™ platform addresses these limitations by directly sequencing intact proteins with high resolution, delivering clear, unambiguous molecular detail.

Through a two-step workflow—intact protein isolation followed by high-precision fragmentation and sequencing—ProteoSight™ accurately maps post-translational modifications and resolves sequence variants that influence structure and function. Benchmark studies demonstrate superior coverage and sequence continuity, even for large, complex proteins.

This tech note details the ProteoSight™ workflow, benchmark results, and its potential to advance biomarker discovery, therapeutic development, and clinical research.

Download the full tech note to learn more.

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